【摘要】 目的探讨CK5/6、CK7、TTF-1和Ki-67对肺黏液表皮样癌的诊断意义。方法应用免疫组织化学检测CK5/6、CK7、TTF-1和Ki-67在13例肺黏液表皮样癌、28例肺腺癌、23例肺鳞状细胞癌(鳞癌)中的表达。结果 CK5/6在黏液表皮样癌与腺癌、CK7在黏液表皮样癌与鳞癌中表达差异均有统计学差异(P<0.01),TTF-1在腺癌中表达显著高于黏液表皮样癌和鳞癌(P<0.01),Ki-67在腺癌和鳞癌中表达均高于黏液表皮样癌(P<0.05)。结论联合检测CK5/6、CK7、TTF-1和Ki-67有助于肺黏液表皮样癌与肺腺癌、鳞癌的鉴别。更多还原

【Abstract】 Objective To study the diagnostic value of CK5/6, CK7, TTF-1 and Ki-67 expression in pulmonary mucoepider-moid carcinoma (MEC).Method CK5/6, CK7, TTF-1 and Ki-67 expression was detected by immunohistochemistry in 13 pulmonary MEC, 28 adenocarcinoma and 23 squamous cell carcinoma (SCC) cases. Results There were significant differences in CK5/6 expression between MEC and adenocarcinoma and in CK7 between MEC and SCC (P<0.01). TTF-1 expression in adenocarcinoma was superior to that in MEC and SCC (P<0.01), while Ki-67 expression was significantly higher in adenocarcinoma and SCC than that in MEC (P<0.05). Conclusion Combined detection of CK5/6, CK7, TTF-1 and Ki-67 expression is helpful for differential diagnosis of pulmonary MEC, adenocarcinoma and SCC.更多还原