【摘要】 目的分析口腔专科医院药品不良反应(adverse drug reaction,ADR)的发生情况,探讨专科医院预防ADR的措施,为临床合理用药提供参考。方法收集广东省口腔医院2010年45例ADR报告,对患者一般情况、药品种类、临床表现、给药途径等进行回顾性分析。结果 45例ADR中,麻醉和骨骼肌松弛药13例(28.89%),影响免疫功能药10例(22.22%),抗微生物药9例(20.00%),抗肿瘤药8例(17.78%)。各种给药方式中,静脉给药引发的ADR位居首位,共31例,占68.89%。ADR临床表现主要为皮肤及附件的过敏反应,共21例,占46.67%。结论分析ADR有利于医药人员加强ADR监测,控制用药风险,促进用药安全。更多还原

【Abstract】 Objective To analyze the cause and induce factors of adverse drug reaction(ADR) in our hospital in 2010,to discuss the possible prevention approach,and to provide reference for rational use in clinic.Methods Forty-five cases with ADR found in our hospital in 2010 were retrospective analyzed.Patients’ general information,types of drugs,clinical manifestations,routes of administration,usage and dosage of the drugs and ADR were investigated,classified and statistically analyzed.Results Among all ADR cases,anesthetic and skeletal muscular relaxants,immunosuppressive,anti-pathogenic microorganism,anti-cancer drugs accounted for 88.89% of adverse reactions.68.89% were induced by intravenous dripping injection.The main clinical manifestations of ADR were lesions of skin and its appendants(46.67%).Conclusion The analysis of ADR is benefit for us to be familiar with adverse drug reactions,timely and effective control of drug risk and to reduce ADR and ensure patient’s safety of drug use.更多还原