【摘要】 以聚丁二酸丁二醇酯(PBS)为参照,研究了酯酶Lipase AY30对亲水磷酰胆碱(PC)基团改性的聚丁二酸丁二醇酯(PBS-PC)的生物降解性能的影响.结果显示,在酯酶Lipase AY30作用下,21 d后PBS的质量损失仅为1.9%,而PBS-PC的质量损失了9.7%.相同条件下扣除各自水解引起的质量损失(PBS 1.4%和PBS-PC 6.5%)后,PC亲水基团的引入对聚合物的降解起到了促进作用.示差扫描量热(DSC)研究结果表明,改性后的聚合物熔融温度和熔融焓降低,玻璃化转变温度升高,表明PC端基的引入降低了PBS的结晶能力,非晶相结构的增多对聚合物降解有促进作用.因此PBS-PC有望作为一种新的具有良好生物降解性和生物相容性的高分子材料,应用于药物控释、基因治疗及组织工程等生物医用材料领域.更多还原

【Abstract】 Enzymatic degradation of poly(butylene succinate)(PBS) and phosphorylcholine functionalized poly(butylene succinate)(PBS-PC) were performed in the presence of lipase AY30.It was found that PBS-PC was effectively biodegraded by lipase AY30,and PBS was hardly degraded even after an experimental time scale of 21 d.By means of differential scanning calorimetry(DSC),thermal properties of PBS and PBS-PC were studied.The results show that the melting point(Tm) of PBS-PC is decreased and glass transition tempe-rature(Tg) is increased compared with unmodified PBS.PBS-PC may have potential applications in biological environments as new carriers for controlled drug release,gene therapy,and scaffold for tissue engineering systems.更多还原