【摘要】 目的观察复方牛胎肝提取物片联合阿德福韦酯片治疗慢性乙型肝炎患者对肝纤维化的临床疗效。方法将42例慢性乙型肝炎患者随机分为治疗组21例,给予口服复方牛胎肝提取物片及阿德福韦酯片和对照组21例,给予口服阿德福韦酯片,疗程均为48周。观察两组患者在治疗前及治疗48周后两次肝穿刺活检病理学变化和血清透明质酸(HA)的变化。结果治疗后治疗组肝组织炎症活动度2例加重,10例无明显变化,9例减轻,对照组肝组织炎症活动度6例加重,12例无明显变化,3例减轻。治疗组肝脏炎症活动度改善优于对照组,差异有显著性(P=0.029);治疗组纤维化程度2例加重,10例无明显变化,9例减轻,对照组纤维化程度9例加重,9例无明显变化,3例减轻。治疗组纤维化程度改善明显优于对照组,差异有显著性(P=0.006);治疗组治疗后HA下降明显(P<0.001),对照组未见降低,两组间差异有显著性(P<0.001)。结论复方牛胎肝提取物片联合阿德福韦酯片能显著地改善肝脏炎症活动度和纤维化程度,优于单用阿德福韦酯治疗。更多还原

【Abstract】 Objective To investigate the effect of compound embryonic bovine liver extract and adefovir dipivoxil treatment on patients with chronic hepatitis B.Methods 42 patients with choronic hepatitis B were divided randomly to two groups.Treatment group was treated with compound embryonic bovine liver extract tablets and adefovir dipivoxil tablets,and control group was treated with adefovir dipivoxil tablets.The regimen lasted for 48 weeks in the two groups.The liver inflammation activity grades and fibrosis stages and serum hyaluromic acid(HA) level before and after treatment in two groups were obtained.Results Grades of liver inflammation activity and stages of fibrosis decreased obviously in treatment group than in control group(P<0.05).At the end of the therapy,serum HA level decreased significantly in treatment group(P<0.001)and there was no decrease in control group(P<0.001).Conclusion Combined therapy of compound embryonic bovine liver extract tablets and adefovir dipivoxil tablets was better than adefovir dipivoxil tablets alone in patients with chronic hepatitis B.更多还原