【摘要】 目的:探讨了血清同型半胱氨酸(Hcy)检测的临床意义。方法:应用化学发光法和放射免疫分析对155例心脑血管病、糖尿病、消化道恶性肿瘤患者进行了血清Hcy和FA、VitB12检测,并与35名正常健康人作比较。结果:心脑血管病、糖尿病、消化道恶性肿瘤患者血清Hcy水平非常显著地高于正常人组(P<0.01),且血清FA、VitB12水平呈显著地低于正常人组(P<0.01)。血清Hcy是动脉硬化性心脑血管病及糖尿病、消化道恶性肿瘤的危险因子。且血清Hcy水平与FA、VitB12水平呈显著负相关(r=-0.4511、-0.5134,P<0.01)。结论:FA、VitB12补充疗法可降低血清Hcy,有可能成为动脉硬化性心脑血管病及糖尿病、消化道恶性肿瘤高Hcy血症的治疗方案。更多还原

【Abstract】 Objective To explore the clinical significance of serum homocysteine,FA and VitB12.Methods Serum Hcy(with CLIA),serum FA,VitB12(with RIA) levels were measured in 155 patients with cardiovascular-cerebral diseases,diabetes and malignant tumors of digestive system as well as 35 normal controls were studied respectively.Results The serum homocysteine level in patients with cardiovascular-cerebral diseases,diabetes and malignant tumors of digestive system was significantly higher than that in controls(P<0.01).But serum FA,VitB12 levels were markedly lower(P<0.01).Serum Hcy level was negative correlated with FA,VitB12 levels(r=-0.4511,-0.5134,P<0.01).The serum homocysteine level is a risk factor of atheromatous cardiovascular-cerebral disease,diabetes and malignant tumor of digestive system.Conclusion The treatment with FA,VitB12 could reduce the serum level of homocysteine.This might be a therapeutic way for hyperhomocystinemia in patients with atheromatous cardiovascular cerebral disease,diabetes and malignant tumor of digestive system.更多还原