【摘要】 目的:探讨CD7和CD56共表达免疫表型对急性髓系白血病（acute myelocytic leukemia,AML）侵袭性的影响。方法:采用多色流式细胞术检测AML患者免疫表型,对6例CD7⁺CD56⁺AML患者和6例CD7^-CD56^-AML患者进行临床资料比较和无病生存（disease-free survival,DFS）率随访。结果:CD7⁺CD56⁺AML在M₀+M₁分型中的分布比例、外周血血红蛋白、骨髓原始细胞比例、中枢系统浸润率均高于CD7^-CD56^-AML,差异具有显著统计学意义（P<0.01或P<0.05）;但平均无病生存期低于CD7^-CD56^-AML,差异具有显著统计学意义（P<0.01）。结论:AML中检出CD7、CD56的共表达的免疫表型意味着预后较差,需加强巩固治疗和中枢系统微小残留病灶监测。更多还原

【Abstract】 Objective To investigate the effect of co-expression of CD7 and CD56 to invasiveness of acute myelocytic leukemia （AML）.Methods The immunophenotype of AML was detected by flow cytometry in 6 patients with CD7⁺ CD56⁺ AML in 6 patients with CD7^-CD56^-AML.Their chnical datas and disease-free survival（DFS） rates were compared.Result The distribution rate in FAB-M₀ + M₁,hemoglobin（Hb） in peripheral blood（PB）,percent of blast cells in bone marrow（BM）,invasion rate of central system of patients with CD7⁺ CD56⁺ AML were significantly higher than patients with CD7^- CD56^- AML（P < 0.01 or P < 0.05 ）.The DFS rate of patients with CD7⁺ CD56⁺ AML was significantly lower than patients with CD7^-CD56^- AML（P < 0.01）.Conclusion The co-expression of CD7 and CD56 indicates a poor prognosis.Enhanced treatment and microresidual disease detection should be performed.更多还原