【摘要】 目的:探讨了慢性乙型肝炎患者血清TGF-β、CTGF、HA和PⅢP的水平变化及其临床意义。方法:应用放射免疫分析和酶联法对36例慢性乙型肝炎患者进行了血清TGF-β、CTGF、HA和PⅢP检测,并与35名正常健康人作比较。结果:慢性乙型肝炎患者血清TGF-β、CTGF、HA和PⅢP水平均非常显著地高于正常人组(P<0.01)。且血清TGF-β水平与CTGF、HA、PⅢP水平呈正相关(r=0.6018、0.5784、0.5584,P<0.01)。结论:检测慢性乙型肝炎患者血清TGF-β、CTGF、HA和PⅢP的水平具有重要的临床价值,这些生物标志物的变化,可提高对病情及预后评估的认识。更多还原

【Abstract】 Objective To investigate the significance of changes of serum TGF-|},CTGF,HA and PMP levels in patients with chronic hepatitis B.Methods Serum TGF-p,HA,PⅢP(with RIA),serum CTGF(with ELISA) levels were measured in 36 cases of patients with hepatitis B,35 normal controls.Results Serum TGF-|J,CTGF,HA and PⅢP levels were significantly higher than those in controls(P<0.01).Serum TGF-βwere positively correlated with the CTGF,HA and PⅢP levels(r =0.6018,0.5784,0.5584, P<0.01).Conclusion Detection of serum TGF-β,CTGF,HA and PⅢP in the patients with chronic hepatitis B provided important clinical values.The changes of such biomarkers can be improved to recognize the process and prognostic evaluation of the disease.更多还原