【摘要】 目的:探讨慢性乙型肝炎、肝硬化、肝癌患者血清IL-8、IL-10和leptin水平的变化及其临床意义。方法:应用放射免疫分析测定35例慢性乙型肝炎、30例肝硬化、27例肝癌患者的血清IL-8、IL-10和leptin水平,并与正常对照组比较。结果:各组患者的血清IL-8、IL-10和leptin水平均较正常对照组显著地增高,相关分析的数据表明,血清leptin水平与IL-8呈正相关。结论:血清IL-8、IL-10和leptin水平的变化与慢性乙型肝炎、肝硬化、肝癌发生发展密切相关。更多还原

【Abstract】 Objective To explore the clinical significance of changes on serum levels of interleukin-8(IL-8),interleukin-10(IL-10) and leptin(LEP) in patients with chronic hepatitis B(CHB),liver cirrhosis(LC),primary hepatocellular carcinoma(PHC). Methods The levels of serum IL-8,IL-10 and leptin were detected by RIA in 35 patients with CHB,30 patients with LC,27 patients with PHC as well as 30 health control respectively.Results The levels of IL-8,IL-10 and leptin in CHB,LC,and PHC groups were dramatically higher than those in control group(P <0.01).Correlation analysis of data proclaimed that level of leptin correlated positively with level of IL-8 in patients(.P <0.01).Conclusion The changes of serum levels of IL-8,IL-10 and leptin may play a certain role in occurrence and development of CHB,LC,and PHC.更多还原