【摘要】 背景与目的肺癌的组织学类型和分化程度对于评估肿瘤的生物学行为、预后及选择治疗方式具有重要意义。本研究旨在探讨表观扩散系数(apparent diusion coecient,ADC)与肺癌组织学类型和分化程度的相关性。方法符合纳入标准的连续肺癌患者115例,行DWI检查(b=500s/mm2)并测量病变的ADC值,用t检验及单因素方差分析分析不同组织学类型及不同分化程度间ADC值的差异,用Spearman相关系数分析ADC值与不同分化程度之间的相关性。结果小细胞肺癌(small celllungcancer,SCLC)与非小细胞肺癌(non-small celllungcancer,NSCLC)的ADC值差异有统计学意义(P=0.017),且SCLC与鳞癌、腺癌的ADC值差异均有统计学意义(P分别为0.011、0.001)。肺癌不同分化程度间的ADC值差异有统计学意义(P=0.003),且ADC值与病变不同分化程度存在相关性(rs=-0.272,P=0.003)。结论ADC值对术前判断肺癌的组织学类型及分化程度有一定意义:小细胞肺癌的ADC值低,分化程度低的肿瘤的ADC值低。更多还原

【Abstract】 Background and objective e histologic type and grade of lung cancer are signi cant in assessingthe biological behaviour, prognosis and therapeutic regimen. is study investigates the correlation of apparent di usion coef-cient (ADC) with histologic type and grade of lung cancer. Methods A total of 115 patients pathologically diagnosed withlung cancer were enrolled in this study. Magnetic resonance (MR)-DWI with a di usion factor of 500 s/mm2was performedand the ADC values of lesions were measured. e ADC values among the di erent histologic types and grades were comparedwith the values obtained using t-test and one-way ANOVA. e correlation between ADC values and the histologic grades wasfurther evaluated with Spearman correlation coe cient. Results With a b value of 500 s/mm2, the ADC values signi cantly dif-fered between small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) (P=0.017). e ADC values of SCLCwere significantly different from those of squamous cell carcinoma and adenocarcinoma (P=0.011, 0.001, respectively). Asigni cant di erence was observed in the ADC values among the di erent histologic grades of lung cancer (P=0.003), and theADC value was correlated with the histologic grades (rs=-0.272, P=0.003). Conclusion ADC value is signi cant for judgementof histologic type and grade of lung cancer before surgical operation: SCLC has a low ADC value, and ADC value is low for thetumor with poorly-di erentiated grade.更多还原