【摘要】 背景与目的临床上肺癌合并严重冠心病患者逐年增多,本文旨在总结同期心肺手术治疗这类患者的临床经验,为临床诊治工作提供参考。方法回顾性分析2003年-2012年我科完成18例同期手术的临床资料。男性16例,女性2例,平均年龄66.11岁。临床TNM分期多为Ⅰ期/Ⅱ期病例,心肺功能良好。结果本组病例无手术死亡及新发心肌梗塞。病理诊断鳞癌10例,腺癌8例,病理TNM分期Ia期2例,Ⅰb期8例,Ⅱa期3例,Ⅱb期3例,Ⅲa期2例。术后常见并发症为心律失常、肺不张、肺部感染。手术时间、术后引流量、带管时间及输血量腔镜组均较开胸组有明显下降,两组生存率无统计学差异(P=0.187)。结论同期手术治疗肺癌合并严重冠心病安全、有效。胸腔镜使用创伤小,效果较确切。更多还原

【Abstract】 Background and objective The number of patients with both lung cancer and coronary heart disease has increased for the last ten years. The aim of this study is to analyze the outcome of the combined treatment of radical surgery and off-pump coronary artery bypass grafting (OPCABG) for patients with both lung cancer and coronary heart disease. Methods The clinical data of 18 patients (16 males and 2 females, mean age of 66.11 years) with both lung cancer and coronary heart disease who went through combined surgical interventions between 2003 and 2012 were summarized and analyzed. The lung cancer in these patients was predominantly at stages Ⅰ and Ⅱ (TNM). All patients’ cardio-pulmonary function was favorable. Results All the patients survived the operation, without any recorded death and new myocardial infarction occurrence during the perioperative period. Squamous carcinoma and adenocarcinoma were found in 10 and 8 patients, respectively. Pathological lung cancer stage was Ⅰa in 2 cases, Ib in 8 cases, Ⅱa in 3 cases, Ⅱ b in 3 cases, and Ⅲa in 2 cases. The most frequently observed complications were cardiac arrhythmias, atelectasis, and pulmonary infections. The mean values of operating room time, postoperative drainage, drainage tube time, and blood transfusion were significantly different between video-assisted thoracoscopic surgery (VATS) groups and thoractomy groups. No significant differences in survival rate were found (P=0.187). Conclusion The combined method of OPCABG and pulmonary resection is a safe and effective treatment for patients with both lung cancer and coronary heart disease. VATS lobectomy is beneficial for lung cancer patients because it reduces lesions.更多还原