【摘要】 目的综合评价人乳头状瘤病毒(humanpapillomavirus,HPV)感染与鼻腔鼻窦内翻性乳头状瘤(sinonasal inverted papillomas,SNIP)发病及复发的关系。方法纳入研究SNIP与HPV感染相关性并采用聚合酶链反应(PCR)法检测HPV的病例对照研究,对纳入研究的质量进行评价,采用Revman5.1软件进行Meta分析。结果①SNIP发病与HPV感染相关性(SNIP组与对照组比较):符合标准的文献15篇,总样本数1068,其中SNIP组664例,对照组404例,Meta分析示SNIP组HPV感染率明显高于对照组(P<0.00001),其合并OR是对照组的25.55倍(95%CI=12.71～51.37);②SNIP复发与HPV感染相关性(SNIP复发组与单纯SNIP组比较):符合标准的文献7篇,总样本数198,其中SNIP复发组57例,单纯SNIP组141例,Meta分析示SNIP复发组HPV感染率明显高于单纯SNIP组(P<0.00001),其合并优势比是对照组的8.11倍(95%CI=3.27～20.13)。结论 HPV感染可增加SNIP发病的危险性,并可能在SNIP复发中起到重要作用。更多还原

【Abstract】 OBJECTIVE To synthetically evaluate the relationship between pathogenesis and recurrence of sinonasal inverted papillomas(SNIP)and human papilloma virus(HPV)infection.METHODS The quality of selected case-control studies that investigated the relationship between pathogenesis and recurrence of SNIP and HPV infection was evaluated.Articles with the polymerase chain reaction approach to detect HPV in specimens were selected,and Meta-analysis was conducted by using the Revman 5.1 software.RESULTS ①The relationship between pathogenesis of SNIP and HPV infection: 15 studies were selected,pooling results of Meta-analysis indicated that HPV infection was associated with the onset of SNIP(combined OR =25.55,95%CI =12.71～51.37,P <0.00001).②The relationship between the recurrence of SNIP and HPV infection: 7 studies were selected,pooling results of Metaanalysis indicated that HPV infection was associated with the recurrence of SNIP(combined OR =8.11,95%CI=3.27～20.13,P<0.00001).CONCLUSION The infection of HPV may enhance the risk of development of SNIP,and may play an important role in it’s recurrence.更多还原