【摘要】 目的探讨杏仁中央核中的N-甲基-D-天冬氨酸(NMDA)型谷氨酸受体对食物和水摄取的影响。方法不锈钢套管植入雄性Sprague-Dawley大鼠一侧杏仁中央核内,NMDA型谷氨酸受体激动剂原型物NMDA,或选择性NMDA受体拮抗剂D()-2-氨基-5-磷酰基戊酸(D-AP-5)微量注射入饱食和含水度正常的大鼠的杏仁中央核内。结果杏仁中央核内注射入8.50,17.00,或34.00 nmol NMDA不改变大鼠摄食量,但是增加注射后0~1 h内不依赖于食物摄取的摄水量(F3,32=3.191,P=0.037)。杏仁中央核内注射入6.34,12.70,或25.40 nmol D-AP-5也不影响大鼠摄食量,但是减少了注射后0~1 h内不依赖于食物摄取的摄水量(F3,28=3.118,P=0.042)。结论杏仁中央核中的NMDA受体可能参与了对摄水而不是摄食的调控。更多还原

【Abstract】 Objective To investigate the role of N-Methyl-D-aspartic acid(NMDA)-type glutamate receptors in the central nucleus of the amygdale(CeA) in food and water intake.Methods Male Sprague-Dawley rats with stainless steel cannulae implanted unilaterally into the CeA were used.The prototypic NMDA receptor agonist NMDA,or the selective NMDA receptor antagonist D(-)-2-amino-5-phosphonopentanoic acid(D-AP-5) was microinjected into the CeA of satiated and euhydrated rats.Results Intra-CeA injection of 8.50,17.00,or 34.00 nmol NMDA did not alter food intake but significantly increased water intake 0-1 h after the injection(F3,32=3.191,P=0.037) independent of food intake.Without affecting the food intake,injection of 6.34,12.70,or 25.40 nmol D-AP-5 into the CeA significantly decreased water intake 0-1 h after the injection(F3,28=3.118,P=0.042) independent of food intake.Conclusion NMDA receptors in the CeA may participate in the control of water intake rather than food intake.更多还原