【摘要】 目的:了解大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌感染现状和对常用抗菌药物耐药趋势。方法:应用VITET-2Compact全自动微生物分析仪进行细菌鉴定,K-B纸片扩散法进行药敏试验。结果:4种革兰阴性杆菌对青霉素类、磺胺类、喹诺酮类、阿莫西林/棒酸、庆大霉素、头孢类、氨曲南耐药率分别为75%、75%、20%、70%、55%、50%、13%,而铜绿假单胞杆菌对头孢他啶(7.22%)和头孢吡肟(11.86%)较为敏感。大肠埃希菌和肺炎克雷伯杆菌均对碳青霉烯类和头孢哌酮/舒巴坦敏感,铜绿假单胞杆菌对其全部耐药,鲍曼不动杆菌仅对亚胺培南、头孢哌酮/舒巴坦敏感。大肠埃希菌和铜绿假单胞杆菌对阿米卡星敏感,肺炎克雷伯杆菌对哌拉西林/他唑巴坦敏感,其它菌耐药率都超过14%。结论:大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌对常用抗生素耐药率高;医院检验科应加强细菌感染控制和耐药监测,指导临床合理使用抗生素。更多还原

【Abstract】 Objective: To investigate the clinical distribution and drug resistance of four kinds of Gram-negative bacillus in Affiliated Hospital of Dali University and provide basis for clinical medicine.Methods: VITET-2 compact automated microbial analyzer was applied for bacterial identification,K-B disk diffusion method were used for drug sensitive test.Results: The drug resistance rates of four kinds of bacilli to penicillins,sulfonamides,quinolones and amoxicillin amoxicillin/clavulanic acid,gentamicin,cephalosporins,aztreonam,resistance rates were 75%、 75%、 20%、 70%、 55%、 50%、 13%,respectively.P.aeruginosa was more sensitive to ceftazidime(7.22%) and cefepime(11.86%).E.coli and K.pneurmoniae were sensitive to both carbapenem and cefoperazone/sulbactam,while P.aeruginosa were resistant to both carbapenem and cefoperazone/sulbactam,A.baumanii was sensitive to imipenem and cefoperazone/sulbactam.E.coli and P.aeruginosa were sensitive to amikacin,K.pneurmoniae was sensitive to piperacillin / tazobactam,but was resistance to others(>14%).Conclusion: There were high drug resistences of 4 Gram-negative bacillus in affiliated hospital of Dali University,hospital should be strengthened infection control,drug monitoring and clinical use of antimicrobial drugs,reducing the emergence of resistant or multi-drug-resistant strains.更多还原