【摘要】 目的:探讨可逆性后部白质脑病综合征(reversible posterior leukoencephalopathy syndrome,RPLS)的临床和影像学特点。方法:本研究为回顾性临床观察。共分析16例可逆性后部白质脑病综合征患者的临床资料。结果:16例患者病因多种,妊娠高血压综合征及先兆子痫7例,继发性高血压3例,原发性高血压3例,肾功能不全3例。主要临床表现视觉障碍、头痛、精神异常和癫痫发作。多数患者头颅MRI表现为双侧大脑后部白质T1WI呈低或等信号,DWI呈等或稍高信号,T2WI和FLAIR像呈高信号,ADC呈高信号,双侧对称或不对称;予以积极对症处理后患者临床症状及影像学表现明显好转。结论:RPLS的病程具有可逆性,脑后部白质损害是其主要特征,及时的诊断与治疗是本病恢复的关键。更多还原

【Abstract】 Objective:To investigate the reversible posterior leukoencephalopathy syndrome(reversible posterior leukoencephalopathy syndrome,RPLS) : clinical and imaging features.Methods:The study was a retrospective clinical observation.Analysis of16 cases of reversible posterior leukoencephalopathy syndrome in patients with clinical data.Results:16 cases of patients with a variety of etiologies,pregnancy-induced hypertension and preeclampsia in 7 cases,secondary hypertension in 3 cases,3 cases of essential hypertension,renal insufficiency in 3 cases.The main clinical manifestations of visual disturbance,headache,mental disorder and epileptic seizures.The majority of patients with MRI scan showed bilateral posterior cerebral white matter T1WI had low-intermediate signal,DWI were equal or slightly high signal,like T2WI and FLAIR showed high signal intensity,ADC showed high signal,bilateral symmetry or asymmetry;be positive after symptomatic treatment in patients with clinical symptoms and imaging performed significantly better.Conclusion:RPLS in the course of the disease is reversible,posterior white matter damage is its main characteristic,and timely diagnosis and treatment of this disease is the key to recovery.更多还原