FLAG方案治疗难治复发白血病疗效观察

【摘要】 目的观察FLAG方案对复发难治白血病的疗效及不良反应。方法氟达拉滨(Flu)30mg/m2.d,d1-5,阿糖胞苷(Ara-C)1.0～2.0/m2.d,d1-5,粒细胞集落刺激因子(G-CSF)300μg/d,氟达拉滨化疗前一天使用,至外周血中性粒细胞数(ANC)>1.0×109/L止。ALL予改良FLAG方案化疗。结果 15例患者中经FLAG方案化疗1疗程获得OR53.3%(8/15),CR40%(6/15),PR13.3%(2/15),NR46.7%(7/15)。15例均出现骨髓抑制现象,ANC回升至0.5×109/L的中位时间为15(8～24)d,14例出现发热,感染率为93.3%。4例出现转氨酶轻度升高。结论 FLAG方案是治疗复发难治白血病较为有效的方法,能为骨髓移植等治疗争取时间。更多还原

【Abstract】 Objective To elevate the effect of FLAG regimen on refractory and relapse leukemia and side effects.Methods 15 cases were treated with Fludarabine 30mg/m2.d,d1-5,Ara-C 1.0～2.0/m2.d,d1-5 and G-CSF 300ug/d.Results overall remission(OR) is 53.3%(8/15),complete remission(CR) is 40%(6/15),partial remission(PR) is 13.3%(2/15),no remission(NR) is 46.7%(7/15) were achieved respectively after one treatment.Conclusion FLAG is an effective regimen for refractory and relapse leukemia which can gain a time span of 1～5 months for hematopoitic stem cell transplantation.The main side effect of this regimen is bone marrow suppression.更多还原