【摘要】 采用溶胶-凝胶法在多孔NiTi合金表面制备出多孔TiO₂/羟基磷灰石（HA）/TiO₂复合涂层,研究了复合涂层的性能。结果表明:与未经过涂层处理的样品相比,涂有复合涂层的样品在模拟体液（SBF）溶液中Ni离子的释放率大大降低;复合涂层具有比单一涂层更好的生物活性,在快速钙化溶液（FCS）中能诱导磷灰石快速生长;多孔NiTi合金的特殊孔道结构为药物的可控释放创造了条件,使药物释放呈现缓慢可控的规律。更多还原

【Abstract】 A porous TiO₂/HA/TiO₂ composite coating was prepared on the surface of a porous NiTi alloy by mixed sol method.The release rates of Ni ion of the porous NiTi alloy of different porosity ratios in the composite coatings in a simulated body fluid decrease markedly compared with the uncoated alloys.The composite coatings have better biological activity than that of a single-layer coating and then can induce the growth of apatite quickly.The release characteristics of gentamicin sulfate loaded on the porous NiTi alloy was also investigated.The results show that the porous NiTi alloy can control the release of drugs by means of the special pore structure,and the drugs show a slow and controlled release pattern.更多还原