Objective To evaluate the merits and demerits of single-voxel and multi-voxel MR Spectroscopy in the detection of the substantia nigra in patients with the Parkinson disease.Methods The content of NAA,Cho and Cr in substantia nigra in 20 patients and 10 age-matched healthy controls were examined with single-voxel and multi-voxel 1H-MRS.The rations of NAA/Cr,Cho/Cr and NAA/Cho were calculated.The quality of spectral line of single-voxel and multi-voxel 1H-MRS were compared.Results The ratios of NAA/Cr,NAA/Ch...