【摘要】 目的观察亚低温治疗对急重型颅脑损伤患者脑脊液中S-100B蛋白水平和血糖以及预后的影响,并探讨其治疗意义。方法将46例急性重型颅脑损伤的患者随机分为亚低温组和常规组。亚低温组在常规治疗的基础上,予亚低温治疗,直肠温度维持在33～35℃,根据病情维持3～5d。所有患者于治疗前及治疗后第2、4、6天动态检测脑脊液中S-100B蛋白及血糖水平。3个月后对患者行格拉斯哥预后评分(GOS评分)。结果亚低温治疗后脑脊液S-100B蛋白及血糖水平与常规组相比差异有统计学意义,GOS评分亚低温组明显优于常规组(P<0.05)。结论早期亚低温治疗能显著降低急性重型颅脑损伤患者脑脊液中S-100B蛋白水平,改善糖代谢紊乱,从而改善患者预后。更多还原

【Abstract】 Objective To observe the effect of mild hypothermia on cerebrospinal fluid S-100B protein level and serum levels of blood glucose and prognosis in acute severe brain injury patients,and to explore its role in treatment of acute severe brain injury.Methods A total of 46 patients with acute severe brain injuries were randomly divided into mild hypothermia group and general group.The patients in mild hypothermia group were treated with hypothermia besides routine treatment,with maintenance of rectal temperature at 33-35℃ for 3-5 days.S-100B and blood glucose were measured in all patients before the treatment and at 2nd,4th,6th day after the treatment.Prognosis was evaluated with GOS at 3 months.Results S-100B and blood glucose level in the mild hypothermia group were lower than those in the general group after the treatment,there was significant difference between the two groups.GOS of treatment group was better than that of general group at 3 months(P<0.05).Conclusion Early use of mild hypothermia can decrease concentration of S-100B protein in cerebrospinal fluid and blood glucose so as to improve prognosis.更多还原