【摘要】 目的探讨大肠癌组织中乙酰肝素酶(Hpa)和血管内皮生长因子-C(VEGF-C)的表达与大肠癌发生、浸润转移及预后的关系。方法采用免疫组织化学Envison法,对大肠癌的癌组织与正常组织中Hpa和VEGF-C表达水平进行测定,结合大肠癌的临床病理学特征及预后进行分析。结果 Hpa和VEGF-C在大肠癌组织、正常组织中表达水平比较,差异有统计学意义(P<0.01)。Hpa和VEGF-C在大肠癌无淋巴结转移与淋巴结转移组,在大肠癌Ⅰ、Ⅱ和Ⅲ、Ⅳ期组织中及生存5年以下组和生存5年和(或)5年以上组表达率比较,差异有统计学意义(P<0.01)。结论 Hpa和VEGF-C在大肠癌组织中的高表达,在有转移(淋巴转移及远处转移)组高表达,说明Hpa和VEGF-C可能在大肠癌的发生、侵袭和转移中起作用。更多还原

【Abstract】 Objective To explore the relationship between heparanase(Hpa),vascular endothelial growth factor-C(VEGF-C)and tumorigenesis,invasion,metastasis,prognosis of colorectal cancer.Methods The Hpa and VEGF-C in colorectal cancer were cheched by immunochemical method and analysis the relation between the results and the clinicopathologic characteristics of colorectal cancer.Results The positive rate of heparanasis and VEGF-C expression were differences in statisticals in tumor and normal tissues of colorectal cancer,in tumor tissues without and with lympy node metastasis,Ⅰ-Ⅱ and Ⅲ-Ⅳstages patients respectively,in patients existing < 5-years and ≥ 5-years(P<0.01).Conclusion The high expression of Hpa and VEGF-C in tumor tissue and with metastasis of colorectal cancer,means that it may play an important role in tumorigenesis,invasion and metastasis of colorectal cancer.更多还原