【摘要】 目的观察白芍总苷(TGP)对寻常性银屑病患者血清瘦素及白细胞介素-18(IL-18)水平的影响,并探讨其作用机制。方法分别采用放射免疫分析法(RIA)和双抗体夹心酶联免疫吸附法(ELISA)检测70例寻常型患者经白芍总苷治疗前、后血清瘦素及IL-18水平变化。结果银屑病患者治疗前血清瘦素及IL-18水平均高于治疗后及正常对照组(P<0.05);经白芍总苷治疗后二者血清水平均较治疗前下降(P<0.05)。结论白芍总苷可能通过影响血清瘦素和IL-18的水平而发挥作用。更多还原

【Abstract】 Objective To observe the influence of total glucosides of paeony(TGP) on the serum leptin and lnterleukin-18(IL-18) levels in the patients with psoriasis vulgaris,and to discuss its functional mechanism.Methods The serum leptin and interleukin-18 levels before and after treatment with TGP in 70 patients with psoriasis vulgaris were detected by RIA and ELISA respectively.Results The serum leptin and interleukin-18 levels before treatment in the patients with psoriasis vulgaris were significantly higher than those after treatment and in the control group(P<0.05).Compared with before treatment,their serum levels after TGP treatment were also significantly reduced(P<0.05).Conclusion TGP may play the therapeutic role through inhibiting the secretion of serum leptin and interleukin-18.更多还原