【摘要】 目的:探讨复方芪苓无糖颗粒剂对高脂血症大鼠血脂调节及肝脏保护作用。方法:将SD大鼠随机分为正常组与造模组,脂肪乳剂建立高脂血症大鼠模型后,将造模组大鼠随机均等分为模型组、血脂康胶囊组、复方芪苓无糖颗粒剂高、中、低剂量组。检测血清总胆固醇(TC)、血清甘油三脂(TG)、血清低密度脂蛋白胆固醇(LDL-C)、血清高密度脂蛋白胆固醇(HDL-C)、超氧化物歧化酶(SOD)、丙二醛(MDA)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)水平。结果:①与模型组比较,各给药组血清TC、LDL-C水平均显著性降低(P<0.01),血清HDL-C水平显著性升高(P<0.01);各给药组血清ALT、AST均有不同程度降低(P<0.01)。②与血脂康组比较,复方芪苓无糖颗粒降低血清TC、LDL-C,升高血清HDL-C均有统计学差异(P<0.05,P<0.01);复方芪苓无糖颗粒高、中剂量组降低血清ALT最显著,有统计学差异(P<0.01)。结论:复方芪苓无糖颗粒具有显著的降血脂、保护肝脏的作用。更多还原

【Abstract】 Objective: To investigate the liver protection of sugar-free Qiling compound Granules by regulating blood lipids in hyperlipidemic metabolism.Methods: The SD rats were randomly divided into normal group and modeling group.When all the model rats were proved to be successful animal model of hyperlipidemia after that,model rats were randomly divided into model of blank control group,Xuezhikang Capsule group,sugar-free Qiling compound Granules of high,medium and lowdose groups.Detecting the serum TC,TG,LDL-C,HDL-C,superoxide dismutase(SOD),malondialdehyde(MDA),Heavenly Gate aspartate aminotransferase(AST),alanine aminotransferase(ALT) levels in femoral artery.Results: ①Compared with model of blank control group: the serum TC,LDL-C levels were significantly decreased(P<0.01) in all the drug groups;the serum HDL-C levels were significantlyinceased(P<0.01)theserumALT,ASTwerereduced(P<0.01)inallthedruggroups.②Compared with the Xuezhikang Capsule group: all the sugar-free Qiling compound Granules groups have reduced serum TC,LDL-C,elevated serum HDL-C(P<0.05,P<0.01);the medium-dose and the high-dose group of sugar-free Qi Ling compound granules groups have the most significant reduction of serum ALT(P<0.01).Conclusion: sugar-free Qiling compound Granules protect liver by lowering blood pressure severely.更多还原