【摘要】 目的:探讨针刺太冲穴前后抑郁症患者脑功能变化的差异。方法:选取符合DSM-IV诊断标准的首发中度抑郁症患者26例及健康志愿者13名,运用3.0T磁共振分别在针刺前后进行静息态功能磁共振扫描,采用比率低频振幅(fALFF)和功能连接的分析方法,各组进行配对t检验比较。结果:与针刺前比较,针刺后正常对照组右侧额叶(BA11)fALFF值降低,抑郁太冲组右侧额叶(BA6)、右侧额中回(BA10)、左侧额上回中部(BA32)、双侧顶下小叶(BA40)、右侧楔前叶(BA7)fALFF值降低,抑郁非穴组左侧顶叶(BA42)、右侧顶叶(BA40)、左侧枕叶(BA17)fALFF值降低,抑郁太冲组左侧前扣带回皮质(BA32)与双侧额叶(BA8、BA46)、右侧颞叶(BA22)、左侧后扣带回(BA23)、双侧顶叶(BA40、BA7)、双侧尾状核功能连接增强。结论:针刺太冲可影响多个脑区功能的变化,并作用于与抑郁症情感调节相关的脑区,这可能是针刺治疗抑郁症的机制。更多还原

【Abstract】 Objective: To explore the changes of cerebral activity pre and after acupuncturing Taichong point.Methods: 26 patients with first-episode moderate depression diagnosed by DSM-IV diagnostic standard and 13 healthy volunteers were collected.Resting-state functional magnetic resonance imaging data were acquired pre and after acupuncture by 3.0 T MRI instrument,analyzed by fractional amplitude of low frequency fluctions(fALFF) and functional connectivity analysis.The results of the two groups were tested by using paired t-test.Results: Compared with data scanned prior to acupuncture,fALFF value of post-acupuncture decreased significantly in right frontal lobe of control group,and in right superior frontal gyrus,right middle frontal gyrus,left superior frontal gyrus,bilateral inferior partietal lobule,right precuneus of depression group.The left anterior cingulate as seed had increased functional connectivity in left medial frontal gyrus,right superior frontal gyrus,right temporal lobe,left posterior cingulated,bilateral parietal lobe and bilateral caudate of depression group.Conclusion: Acupuncturing Taichong point can regulate the cerebral activity in several brain areas and some of them correlated with emotion,which may be the mechanism of acupuncture treatment for depression.更多还原