【摘要】 目的:寻找活性更好的查尔酮类细胞周期蛋白依赖性激酶(CDKs)抑制剂。方法:经查尔酮路线制备8个查尔酮类类黄酮。结果:目标化合物结构经IR、1H-NMR、ESI-MS确证。活性测定结果显示有2个化合物对A549的抑制活性高于对照Flavopiridol,所有化合物对HCT116有较强的抑制活性。结论:Flavopiridol被结构类似的查尔酮代替后,可得到活性更好的类黄酮。更多还原

【Abstract】 Objective: To search chalcones with higher cyclin-dependent kinase(CDKs) inhibitive activity.Methods: Chalcone route was applied to synthesize 8 chalcones.Results: The structures of target compounds were confirmed by IR,1H-NMR and ESI-MS.The results of activity determination indicated that two compounds exhibited higher inhibitive activity against A549 than flavopiridol,and all compounds demonstrated higher inhibitive activity against HCT116.Conclusion: Flavonoids with higher activity could be found if flavopiridol was replaced by chalcones.更多还原