【摘要】 目的神经元动作电位的放电脉冲间隔(interspike interval,ISI)序列包含丰富的时空编码信息,但这种丰富的时空编码信息所蕴含的生理信息没有得到很好的揭示,本文采用样本熵工具量化并分析ISI序列中可能包含的生理信息。方法采用胞外多通道微电极记录猫的初级视皮层神经元对正弦光栅的反应动作电位,在不同时间尺度下采用抖动方法生成与原始动作电位序列在编码层次上等价的ISI序列,然后利用样本熵工具分析这些ISI序列包含的生理信息,将样本熵与神经元发放率进行关联分析。本文还研究了猫初级视觉皮层细胞的方位选择性与样本熵的关系,并分析不同时间尺度对样本熵的影响。结果神经元的样本熵与发放率之间呈反相关关系,并在所有时间尺度上都显著。在猫初级视觉皮层8个细胞的方位选择性与样本熵之间的关系中,6个细胞具有显著反相关关系。而时间尺度的选择对样本熵的影响较小,呈弱反相关关系。结论基于样本熵的神经元ISI序列分析结果表明,样本熵一定程度上反映细胞的生理信息,为研究其他神经体系动作电位包含的生理信息提供参考。更多还原

【Abstract】 Objective Interspike intervals(ISI) of neuron action potentials contain a store of spatiotemporal coding information,yet the physiologic information in the spatiotemporal coding information was not revealed well.In this research,the physiologic information was quantified and analyzed in the ISI series by sample entropy(SampEn) method.Methods Using extracellular multi-unit in vivo recording,response action potential for sinusoidal gratings stimulus in cat primary visual cortex was recorded in this paper.And the jitter method was proposed to create new ISI series that were equivalent to original ones in different time scales.Physiologic information in ISI series was analyzed based on SampEn.This paper analyzed the correlation between SampEn and firing rate,the relationship between SampEn and direction selectivity,and the change of the SampEn with time scales.Results SampEn of neurons was of significantly negative correlation with firing rate in the whole time scales,and was of remarkably negative correlation with direction selectivity on six of eight neurons.And the SampEn of neurons was of weakly negative correlation with time scales.Conclusions SampEn reflects physiologic information of neurons in a certain degree and provides a reference for the physiologic information research of ISI series in nervous system.更多还原