【摘要】 目的探讨协同刺激分子B7-H3在结直肠癌中的表达与患者临床病理参数的相关性。方法收集2003年1月至2003年12月在苏州大学附属第四医院行手术切除术的结直肠癌患者组织标本98例,采用免疫组织化学方法检测结直肠癌组织中协同刺激分子B7-H3的表达,分析B7-H3分子在结直肠癌组织中的表达水平。结果 B7-H3分子在结直肠癌癌灶及间质中均高表达,与患者的年龄、性别、肿瘤分期、分化程度无相关性(P>0.05),但间质高表达B7-H3分子与患者淋巴结转移显著相关(P<0.05)。结论协同刺激分子B7-H3在结直肠癌间质中高表达与患者淋巴结转移相关,对结直肠癌患者的预后判断具有潜在的临床应用价值。更多还原

【Abstract】 Objective To investigate the correlation between the negative costimulatory molecule B7-H3 expression and clinicopathological parameters in colorectal correlation.Methods 98 patients of colorectal cancer in the Forth Affiliated Hospital of Soochow University from January 2003 to December 2003,immunohistochemistry was used to detect colorectal cancer tissues costimulatory molecules B7-H3 expression,analysis of the expression levels of B7-H3 molecules in colorectal cancer tissues and correlation with clinicopathological parameters.Results B7-H3 molecule highly expressed in colorectal cancer foci and interstitial,and there was no correlation with the patient’s age,gender,tumor stage,differentiation degree(P > 0.05 ),but high expression of B7-H3 molecular in interstitial has significant correlation with lymph node metastasis in patients(P <0.05).Conclusion Negative costimulatory molecules B7-H3 is highly expressed in colorectal cancer foci and interstitial.High expression of B7-H3 molecular in interstitial has significant correlation with lymph node metastasis in patients,and has potential clinical value of prognosis in colorectal cancer patients.更多还原