【摘要】 目的分析该院2010年药品不良反应(ADR)发生的原因与特点,了解ADR发生的规律与影响因素。方法对该院2010年上报的137例ADR报告,按患者年龄、性别、给药途径、引起ADR的药品种类、涉及器官或系统及主要临床表现、ADR报告来源等进行统计、分析。结果 60岁以上患者ADR发生率最高(21.17%);静脉滴注较其他给药途径更易发生ADR(52.55%);137例ADR共涉及80种药品,其中抗感染药物居首位(53.28%),其次是中药制剂(16.79%);临床表现以胃肠道系统损害最常见(30.11%);ADR主要由药师和临床药师报告(94.16%)。结论应加强ADR监测和报告,确保临床安全、有效、合理用药。更多还原

【Abstract】 Objective To analyze the causes,features and influencing factors of adverse drug reactions(ADR) in a hospital.Methods 137 ADR case reports collected in the second Affiliated Hospital of Anhui Medical University in 2010 were analyzed statistically in respect of patients age,sex,route of administration,category of the drugs,organ or systems involved,clinical manifestation and source of the ADR reports.Results The ADR incidence rate(21.17%) in the patients over 60 years was highest.The ADRs were more likely caused via intravenous dip(52.55%).Eighty drugs were involved in the 137 ADRs,mainly anti-infective drugs(53.28%),followed by traditional Chinese medicines(16.79%).The ADR were chiefly characterized by gastrointestinal lesions(30.11%).The ADRs were mainly reported by pharmacists and clinical pharmacists.Conclusion ADR monitoring and reporting should be strengthened to ensure safe,effective and rational drug use in the clinic.更多还原