【摘要】 目的:探讨骨髓增生异常综合征（myelodysplastic syndrome,MDS）患者血清β₂-微球蛋白（β₂-microglobulin,β₂-MG）和乳酸脱氢酶（lactic dehydrogenase,LDH）检测的临床价值。方法:采用放射免疫法测定血清β₂-MG,速率法检测LDH,比较两者在30例健康体检者和45例不同亚型MDS患者中的水平,并对两者均增高和均正常的MDS患者进行生存分析。结果:各组MDS患者血清β₂-MG水平均明显高于正常对照组（P<0.01）,其中难治性贫血伴原始细胞过多-Ⅱ（refractory anemia with excessive blastsⅡ,RAEB-Ⅱ）组明显高于难治性贫血（refractory anemia,RA）、难治性血细胞减少伴有多系发育异常（refractory cytopenia with multilineagedysplasia,RCMD）和难治性贫血伴原始细胞过多-Ⅰ（refractory anemia with excessive blastsⅠ,RAEB-Ⅰ）组,差异均有统计学意义（P均<0.01）;RAEB-Ⅰ、RAEB-Ⅱ组血清LDH水平明显高于RA、RCMD组（P<0.01）;血清LDH、β₂-MG均增高的患者中位生存期明显短于两者均正常者（P<0.01）。结论:联合检测血清β₂-MG和LDH水平,对于MDS的诊断、分型及预后分析具有重要的临床价值。更多还原

【Abstract】 OBJECTIVE:To explore the clinical value of the determination of serumβ₂-microglobulin（β₂- MG） and lactic dehydrogenase（LDH） in patients with myelodysplastic syndrome（MDS）.METHODS:Serumβ₂-MG was determined by radioimmunoassay.Serum LDH was detected by velocity method.The levels ofβ₂-MG and LDH were compared between 30 healthy people and 45 patients with different types of MDS groups.The survival analysis of MDS patients with high and normal level ofβ₂-MG and LDH was made and compared.RESULTS:The levels of(β₂-MG in all of MDS groups were significantly higher than that in control group（P<0.01）.β₂-MG in RAEB-II group were significantly higher than that in RA,RCMD and RAEB-I group（P<0.01）.The levels of LDH in RAEB-I,RAEB-II groups was significantly higher than that in RA and RCMD groups（P<0.01）.Median survival time of the patients with high levels of LDH andβ₂-MG was significantly shorter than that of the patients with normal LDH andβ₂-MG（P<0.01）. CONCLUSION:Combined determination of the levels of serumβ₂-MG and LDH could confer important clinical significance in the diagnosis,classification and prognosis of MDS.更多还原