【摘要】 目的观察推拿治疗原发性痛经(primary dysmenorrhea,PD)的疗效,探讨其对PD患者子宫动脉血流动力学参数和血清前列腺素的影响。方法 60例PD患者随机分为推拿组和对照组,每组30例,分别给予推拿手法及口服布洛芬缓释胶囊,连续治疗3个月经周期。采用视觉模拟评分(visu alanalogue scale,VAS)评价疼痛程度,检测两组治疗前后子宫动脉血流动力学参数[搏动指数(PI),阻力指数(RI),收缩期峰值/舒张期峰值(S/D)比值]及经期血清前列腺素F2α(PGF2α)、前列腺素E2(PGE2)含量。结果治疗前两组各项指标比较,差异均无统计学意义(P>0.05)。治疗后推拿组VAS读值(mm,33.17±7.93 vs 63.53±9.48)、PI(2.18±0.18 vs 2.74±0.23)、RI(0.67±0.09 vs 0.86±0.27)、S/D(5.44±0.47vs7.56±0.28)比值及血清PGF2α含量(ng/L,28.10±2.41 vs3 7.68±2.16)低于同期对照组,PGE2含量(ng/L,29.82±2.13 vs 26.43±1.42)高于对照组,差异均有统计学意义(P<0.05,P<0.01)。结论推拿治疗PD疗效显著,其机制可能通过改善子宫动脉高阻、低速的血流特征,调节异常的PGF2α及PGE2水平,发挥止痛效应。更多还原

【Abstract】 Objective To observe the curative effect of massage in the treatment of primary dysmenorrhea(PD),and its effect on hemodynamics parameters of uterine artery and serum prostaglandins.Methods 60 PD patients were randomly assigned to the massage group and the control group,30 in each.Patients in the massage group received massage,while those in the control group orally took ibuprofen sustained release capsule,both for three menstrual cycles.The pain degree was assessed using visual analogue scale(VAS).The hemodynamics parameters of uterine artery [including pulsatility index(PI),resistance index(RI),systolic to diastolic peak ratio(S/D)],the serum levels of prostaglandin F2α(PGF2α) and PGE2 in the menstruation were detected in the two groups before and after treatment.Results There was no statistical difference in each index before treatment between the two groups(P>0.05).Compared with the control group after treatment,the scores of VAS(mm,33.17±7.93 vs 63.53±9.48),PI(2.18±0.18 vs 2.74±0.23),RI(0.67±0.09 vs 0.86±0.27),S/D(5.44±0.47 vs 7.56±0.28),and serum PGF2α level(ng/L,28.10±2.41 vs 37.68±2.16) were lower and serum PGE2 level(ng/L,29.82±2.13 vs 26.43±1.42) higher in the massage group,showing statistical difference(P<0.05,P<0.01).Conclusions Massage had favorable therapeutic effect on PD.Its effect might be achieved through improving the blood circulation of uterus,adjusting the abnormal levels of PGF2α and PGE2,thus exerting pain relief effect.更多还原