【摘要】 目的:探讨蛋白质磷酸酶2A癌性抑制因子(cancerous inhibitor of protein phosphatase2A,CIP2A)在非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达及其临床意义。方法:应用免疫组织化学法检测97例NSCLC组织及其相应癌旁组织中CIP2A蛋白的表达情况,分析CIP2A蛋白表达与NSCLC患者临床病理特征及预后之间的关系。结果:NSCLC组织中CIP2A蛋白的阳性表达率[76.3%(74/97)]明显高于其相应的癌旁组织[5.2%(5/97)],差异有统计学意义(P<0.01)。CIP2A蛋白阳性表达与NSCLC患者的年龄、性别、吸烟情况、组织学类型、TNM分期、肿瘤分化程度、肿瘤大小及淋巴结转移均无明显关系(P>0.05)。CIP2A蛋白阳性表达组患者的总生存时间短于阴性组患者,差异有统计学意义(P=0.001)。CIP2A蛋白表达、TNM分期和肿瘤分化程度是NSCLC患者预后的独立影响因素(P<0.05)。结论:CIP2A蛋白在NSCLC组织中高表达,且其阳性表达与NSCLC患者预后有关。更多还原

【Abstract】 Objective:To investigate the expression of cancerous inhibitor of protein phosphatase 2A(CIP2A) in non-small cell lung cancer(NSCLC) tissues and its clinical significance.Methods:The expressions of CIP2A protein in NSCLC tissues and their corresponding para-cancerous tissues from 97 cases of NSCLC were detected by immunohistochemistry.The relationship between the expression of CIP2A protein and the clinicopathological features in patients with NSCLC was analyzed.Results:The positive expression rate of CIP2A protein in NSCLC tissues [76.3%(74/97)] was significantly higher than that in the corresponding para-cancerous tissues [5.2%(5/97)](P<0.01).The positive expression of CIP2A protein was not associated with age,gender,smoking status,histological type,TNM stage,differentiation of tumor,tumor size and lymph node metastasis(P>0.05).The overall survival time of patients with positive expression of CIP2A protein was shorter than that of patients with negative expression of CIP2A protein(P=0.001).The expression of CIP2A protein,TNM stage and the differentiation of tumor were independent prognostic factors of NSCLC(P<0.05).Conclusion:The expression of CIP2A protein is significantly increased in NSCLC tissues,and the positive expression of CIP2A protein is associated with the prognosis of patients with NSCLC.更多还原