【摘要】 目的:评价锰超氧化物歧化酶(manganese superoxide dismutase,MnSOD)基因多态性与前列腺癌、食管癌及肺癌易感性的关系。方法:计算机检索Cochrane Library和PubMed等数据库,并辅以手工检索,按照纳入与排除标准选择病例-对照研究。评价质量及提取资料后,采用STATA11.0软件对数据进行Meta分析。结果:共纳入22个病例-对照研究,其中病例组8181例,健康对照组11844例。对于前列腺癌,共纳入12个病例-对照研究,其中患者4182例,健康对照6885例,Meta分析结果显示MnSOD基因多态性明显增加了前列腺癌的发病风险[杂合子模型:比值比(odds ratio,OR)=1.11,95%可信区间(confidence interval,CI)=1.01～1.22;纯合子模型:OR=1.25,95%CI=1.03～1.51;显性模型:OR=1.15,95%CI=1.01～1.31)。对于食管癌,共纳入4个病例-对照研究,其中患者620例,健康对照909例,Meta分析结果显示MnSOD基因多态性亦明显增加其发病风险(杂合子模型:OR=1.58,95%CI=1.22～2.04;纯合子模型:OR=2.25,95%CI=1.61～3.15;隐性模型:OR=1.69,95%CI=1.07～2.67;显性模型:OR=1.74,95%CI=1.36～2.22)。然而,对于肺癌,共纳入6个病例-对照研究,其中患者3375例,健康对照4050例,Meta分析结果显示MnSOD基因多态性明显降低了肺癌的发病风险(纯合子模型:OR=0.68,95%CI=0.59～0.78;隐性模型:OR=0.71,95%CI=0.54～0.93;显性模型:OR=0.83,95%CI=0.75～0.92)。结论:MnSOD基因多态性可增加前列腺癌和食管癌的发病风险,但降低肺癌的发病风险。更多还原

【Abstract】 Objective:To evaluate the associations of manganese superoxide dismutase(MnSOD) genetic polymorphism with the susceptibilities of prostate,esophageal and lung cancers. Methods:Studies were identified by searching computerized databases(Cochrane Library,PubMed,etc.) ,accompanied by manual search. The case-control studies were selected according to defined inclusion and exclusion criteria. After quality evaluation and data abstraction,a meta-analysis was performed by using STATA 11.0 software. Results:A total of 22 case-control studies were eligible for this analysis,including 8 181 cases and 11 844 healthy controls. For prostate cancer,12 case-control studies included 4 182 cases and 6 885 healthy controls. Meta-analysis showed that MnSOD polymorphism could significantly increase the risk of prostate cancer [heterozygote genotype:odds ratio(OR) =1.11,95% confidence interval(CI) =1.01-1.22;homozygote genotype:OR=1.25,95%CI=1.03-1.51);dominant genotype:OR= 1.15,95%CI=1.01-1.31) ]. For esophageal cancer,4 case-control studies contained 620 cases and 909 healthy controls. Meta-analysis showed that MnSOD polymorphism could significantly increase the risk of esophageal cancer [heterozygote genotype:OR=1.58,95%CI=1.22-2.04;homozygote genotype:OR= 2.25,95%CI=1.61-3.15);recessive genotype:OR=1.69,95%CI=1.07-2.67);dominant genotype:OR= 1.74,95%CI=1.36-2.22) ]. For lung cancer,6 case-control studies contained 3 375 cases and 4 050 healthy controls. Meta-analysis showed that MnSOD polymorphism could significantly decrease the risk of lung cancer [homozygote genotype:OR=0.68,95%CI=0.59-0.78);recessive genotype:OR= 0.71,95%CI=0.54-0.93);dominant genotype:OR=0.83,95%CI=0.75-0.92) ]. Conclusion:MnSOD polymorphism is associated with elevated risks of prostate and esophageal cancers,but decreased risk of lung cancer.更多还原