【摘要】 目的:探讨"改良解胃磷"(解胃磷)对口服有机磷急性中毒的解毒作用,寻找具有口服解除有机磷毒性的洗胃剂,争取第一时间控制病情,减少阿托品和氯磷定的用药量,减少两重、三重中毒,降低死亡率,减少住院时间和医疗费用。方法:把口服有机磷农药急性中毒经我院首诊并服用解胃磷患者设为治疗组,把外院经过传统洗胃和治疗后再转至我院的患者设为对照组。结果:治疗组注射阿托品和氯磷定的剂量明显少于对照组,给药量多集中在洗胃时间,迅速出现稳定的阿托品化,并发症明显降低,平均住院时间明显缩短,死亡率<1%。结论:"解胃磷"能有效阻止口服有机磷的吸收,明显减少阿托品及肟类复能剂的用量,未见不良反应,是一种能解除口服有机磷毒性的新型消化道解毒剂。更多还原

【Abstract】 Objective:The aim is to find a kind of lavage agent with the function of relieving the poisoning of the organophosphorus,control the patient’s condition at the beginning,decrease the dosage of atropine and pyraloxime methylchloride,reduce double or threefold poisoning,decline the rate of death,reduce hospital stays and expenses. Method:Treatment group include patients with acute poisoning by taking organophosphorus pesticide on their first treatment in the hospital. Control group include patients treated by traditional lavage method in the other hospital.Result:Compared to the control group,the dosage of atropine and pyraloxime methylchloride was less need in the treatment group,which mostly administered on the lavage. Moreover,the stable atropinization appeared quickly,both of the complications and the hospital stays were reduced obviously in treatment group. The death rate were obviously different(P<0.01) . Conclusion:The reformed introgastric phosphorus liquor effectly decrease the absorption of the organophosphorus,reducing the dosage of atropine and reactivation agent with oxime. The adverse reaction was not found. It implied that the reformed introgastric phosphorus liquor is a notive gastral antidote against poisoning by orally taking organophosphorus.更多还原