【摘要】 目的孕中期产前筛查在临床中的应用和意义。方法应用时间分辨法,以血清AFP、free-β-HCG作为指标,对3651例孕15周~20周+6孕妇进行血清学产前筛查,Risk2T软件计算风险值。结果检出唐氏综合征高危孕妇241例,随访发现5例唐氏综合症患儿,低危孕妇3390例,随访发现1例唐氏综合症患儿;检出13/18三体高危孕妇20例,随访未发现患儿;检出开放性神经管缺陷高危孕妇30例,随访发现2例无脑儿。结论孕中期产前筛查可降低出生缺陷的发生。更多还原

【Abstract】 Objective:To explore the clinical application and value in prenatal screening of Down’s syndrome and open nervous tube defect on middle period pregnancy.Methods: Serum samples were collected from 3651 pregnant women on middle period pregnancy(15-20+6week) and free-β-human chorionic gonadot ropin(free-β-hCG) and alphafetoprotein(AFP) level were determined by time-resolved fluoroimmunoassay(TR-FIA,or DELFIA) method.Risk2T was used to calculate the risk rate of Down’s syndrome(DS),13/18 trisomy syndrome and open nervous tube defect(ONTD).Results: The calculated results show that 241,20 and 30 cases were with high risk of DS,13/18 trisomy syndrome and ONTD in 3651 test samples,respetively.After-birth visit on the high-risk pregnant women indicated that 5 births suffered DS,no birth suffered 13/18 trisomy syndrome and 2 births suffered ONTD.Among 3390 low-risk cases of DS,there was also one birth suffered DS.Conclusion: The results in this paper indicate that prenatal screening of middle period serum of pregnant women can reduce the risk of birth defects incidence.更多还原