【摘要】 目的调查分析西安地区0-5岁儿童骨碱性磷酸酶(NBAP)活性分布,为防治儿童维生素D缺乏提供依据。方法对1140名0-5岁儿童应用NBAP试剂盒进行检测。结果 1.NBAP异常检出率为39.83%。结合临床症状等确诊为维生素D不同程度缺乏的儿童占29.74%。2.受检男、女NBAP检测结果之间无显著性差异。3.1岁以下组NBAP异常检出率最高,3～5岁组最低。结合临床症状等确诊为维生素D不同程度缺乏的儿童也随年龄的增长呈下降趋势。4.NBAP结果与季节有关,冬春季异常检出率明显高于夏秋季。结论 NBAP异常检出率和维生素D不同程度缺乏的儿童随年龄的增长均呈下降趋势。西安地区0-5儿童NBAP活性异常检出率较高,有很大一部分儿童处于维生素D缺乏的亚临床状态,预防儿童维生素D缺乏的任务刻不容缓。更多还原

【Abstract】 Objective: To evaluate the neonatal bone alkaline phophatase(NBAP) activity in 0 to 5 year old children from Xi′an for diagnosis of vitamin D deficiency.Methods:Assess the NBAP activity in 1140 children from Xi′an at age 0-5 year old using commercial kit.Results: 1.39.83% of children participated in this study were with aberrant NBAP activity.Along with clinical symptoms,29.74% of the children are diagnosed as vitamin D deficient though in different degrees.2.There was no statistically significant difference between different genders in terms of NBAP activity.3.The percentage of children diagnosed as vitamin D deficient inversely correlated with the age of the children.Abnormal NBAP level was most prevalent in the group of children less than 1 year old.Conversely,the percentage of children with abnormal NBAP activity was lowest among 3-5 year old children.4.There was a correlation between NBAP and the season,as the percentage of children with aberrant NBAP level was much higher in winter and spring as compared with that in summer and winter.Conclusion: Both the prevalence of abnormal NBAP activity and vitamin D deficiency inversely correlates with the age of the children.The percentage of children with abnormal NBAP activity was rather high in Xi′an,surging coming up measures to prevent vitamin D deficiency in children.更多还原