【摘要】 目的:探讨电针对骨质疏松大鼠骨量及胰岛素样生长因子的影响。方法:将50只雌性未孕Wistar大鼠随机分为正常组、模型组、假手术组、雌激素组、电针组,采用双侧卵巢摘除术复制骨质疏松模型,造模成功后,治疗3个疗程,检测大鼠骨密度、骨矿含量及血清中IGF-1I、GF-2的变化。结果:骨质疏松大鼠BMD和BMC的含量明显降低,血清中IGF-1显著降低,与正常大鼠相比,有显著性差异;雌激素组、电针组大鼠BMD、BMC及血清中IGF-1含量明显增加,与模型组相比,有显著性差异。各组IGF-2变化不明显。电针组与雌激素组之间无显著性差异。结论:电针可提高骨质疏松大鼠骨量,可能是通过调节胰岛素样生长因子表达来实现的,其作用效果与雌激素作用效果相近。更多还原

【Abstract】 Objective:To study the effect of electro-acupuncture on bone quantity and insulin-like growth factor in osteoporosis rats.Methods: 50 female Wister rats were randomly divided into control,sham operation,model,estrogen,electro-acupuncture groups.After the bilaterally ovariectomized rats were made successfully and treated for 3 courses.The bone density and hepatic IGF-1、IGF-2 were measured.Results: In the model group,BMD,BMC and IGF-1 were significantly lower than that in the control(P<0.05).BMD、BMC and IGF-1 significantly increased in the two treatment groups after treatment.There was no significant difference between the estrogen group and the electro-acupuncture group.IGF-2 has no obvious change in the five groups.Conclusion: Electro-acupuncture influences insulin-like growth factor and bone quantity in osteoporosis rats.更多还原