【摘要】 目的:研究复方乌黄水凝胶的制备方法,优选工艺条件。方法:以复方乌黄水凝胶中乌头碱含量为指标,考察壳聚糖用量、海藻酸钠用量、交联时间、交联温度四个因素对复方乌黄水凝胶的制备工艺的影响。结果:壳聚糖,海藻酸钠,中药浸膏用量比例为2:6:1,交联40 min,交联温度30℃时水凝胶性能较好,并且凝胶中的乌头碱含量最高。结论:以壳聚糖为辅料,海藻酸钠为交联剂制成的水凝胶性能较好,载药量最大。更多还原

【Abstract】 Objective:To prepare compound Wuhuang hydrogel and optimize the preparation process.Method:The content of aconitine in the hydrogel as the index,the amount of chitosan and sodium algenate,crossing-linking time and temperature as the impact factors,the preparation process of compound Wuhuang hydrogel was optimized.Result:When the amount ratio of chitosan,sodium algenate and extract was 2:6:1,cross-linking time was 40 minutes,and the cross-linking temperature was 30℃,the hydrogel performance was the best,and the content of aconitine in the hydrogel was the highest.Conclusion:Chitosan as the base material and sodium algenate as the cross-linking agent,the hydrogel has promising properties and the drug loading is the highest.更多还原