【摘要】 目的观察不同加碘浓度食盐对人群碘营养状况的影响,探索合适的盐碘浓度。方法采用现场干预研究,将600户杭州市城乡居民随机分成3组,分别提供含碘浓度为(25±2)、(15±2)和(5±2)mg/kg的碘盐,采用单盲法进行30 d的干预试验。检测观察对象干预前后的尿碘水平。同时采用3日称量法测定每日盐摄入量,检测干预前观察对象实际食用碘盐盐碘含量,以及当地水源水和部分用户饮用水水碘含量。结果当地水碘含量为2.05μg/L,其中城区水碘均数为2.25μg/L,农村为1.62μg/L;城区居民每日食盐摄入量为7.17 g/d,农村居民为10.20 g/d;干预前碘盐合格率为97.88%,盐碘浓度为30.09 mg/kg;城区居民尿碘中位数为139.61μg/L,农村居民为279.67μg/L。干预30 d后3个干预组尿碘中位数城区分别为129.52、116.45和112.44μg/L,农村分别为212.58、181.17和157.66μg/L。结论杭州市是碘缺乏地区,必须继续实施食盐加碘策略。但由于农村人群碘营养水平超过适宜量,碘盐浓度可作适当下调,合适的碘盐浓度为20～25 mg/kg。更多还原

【Abstract】 Objective To evaluate the influence of different salt iodine concentration on iodine nutritional status of the target population in Hangzhou district and to determine the appropriate level of salt iodization to the local people.Methods A intervention study was conducted with 600 families,which was randomly divided into 3 groups and took(25±2),(15±2) and(5±2)mg/kg iodized salt respectively.The urinary iodine level was tested before and after the intervention.Meanwhile,daily meal investigation was conducted with 3 days weighing method.Results The median of local water iodine content was 2.05 μg /L,2.25 μg /L in city,and 1.62 μg /L in countryside respectively.The salt intake was 7.17 g/d in city and 10.20 g/d in the countryside.The qualified rate of iodized salt and salt iodine content were 97.88% and 30.09 mg/kg before intervention.The medians of baseline urinary iodine of the subjects were 139.61 μg/L in city and 279.67 μg/L in countryside.The urinary iodine medians for the 3 groups were 129.52,116.45 and 112.44 μg/L in city;212.58,181.17 and 157.66 μg/L in countryside,respectively,in 30 days after intervention.Conclusion Hangzhou district is an iodine deficiency area.The average urinary iodine level in the countryside was slightly higher than the standard level,according to the baseline survey.The intervention trail showed that the salt iodine concentration of 20-25 mg/kg is sufficient to the local people.更多还原