【摘要】 目的探讨支气管哮喘患儿不同时期血清白细胞介素(IL)-10、内皮素(ET)-1与IgE水平的变化及临床意义。方法采用酶联免疫(ELISA)法测定不同时期支气管哮喘患儿血清IL～10、ET-1和IgE水平,并与正常对照组进行统计分析。结果哮喘急性发作组血清IL-10水平显著低于缓解组和对照组(P<0.05),而ET-1和IgE水平却显著高于缓解期和对照组(P<0.05)。IL-10与IgE呈负相关(r=-0.574,P<0.05),而ET-1与IgE呈正相关(r=0.587,P<0.05)。结论 IL-10和ET-1参与支气管哮喘发病的整个过程,IL-10降低和ET-1升高是哮喘发病的重要因素;在支气管哮喘患儿不同时期检测血清IL-10和ET-1水平具有重要的临床意义。更多还原

【Abstract】 Objective To investigate the different periods of bronchial asthma in children with serum levels of interleukin (IL) - 10,endothelin(ET) - 1 and the changes in IgE levels and clinical significance.Methods Using enzymelinked immunosorbent(ELISA) was used to determine the serum of asthmatic children during IL - 10,ET - 1 and IgE levels, and with the control group for statistical analysis.Results Of acute asthma levels of serum IL - 10 significantly lower than the remission group and control group(P < 0.05),while ET - 1 and IgE levels are significantly higher than those in remission and the control group(P < 0.05).IL - 10 and IgE was negatively correlated(r = - 0.574,P < 0.05),while ET- 1 and IgE were positively correlated(r =0.587,P <0.05).Conclusion IL - 10 and ET - 1 in the whole process of bronchial asthma,IL - 10 reduction and increased ET - 1 is an important factor in the pathogenesis of asthma;in different periods of bronchial asthma IL - 10,and serum ET - 1 levelshave important clinical significance.更多还原