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帕利哌酮缓释片临床用药指导意见
Clinical recommendation on paliperidone extended-release tablet in schizophrenia therapy
【摘要】 精神分裂症是一组病因未明的精神疾病,其病程迁延,易慢性化,多数患者会出现精神残疾。目前的治疗目标不仅是控制症状,还要改善患者的社会功能。文中综述了帕利哌酮缓释片的药理特点,并就其临床使用提出指导意见。帕利哌酮缓释片是一种新型第二代抗精神病药,其有效成分帕利哌酮是利培酮的活性代谢产物,同时OROS控释技术可以带来平稳的血药浓度。帕利哌酮缓释片起效迅速,能够全面有效控制症状,安全性良好,同时可以显著改善患者的社会功能。
【Abstract】 Schizophrenia is a group of disabling disorders with uncertain cause.Its course can be presented as one episode or span into a chronic state,ultimately requiring lifelong treatment.The treatment goals of schizophrenia are to rapidly control symptoms,and to gain a result of improved personal and social functioning.In this paper,clinical recommendation on paliperidone extended-release(ER) tablet in schizophrenia therapy was reviewed.Paliperidone ER is a recently developed atypical antipsychotic drug available for the treatment of schizophrenia.Paliperidone(9-hydroxy risperidone) is the major active metabolite of risperidone.By the unique extended-release delivery system,paliperidone ER can steadily deliver paliperidone and maintain steady plasma concentrations.It is efficacious in improving symptoms and social functioning of schizophrenia patients,and is well tolerated.
【Key words】 schizophrenia; paliperidone ER; clinical recommendation; rational medication;
- 【文献出处】 中国新药杂志 ,Chinese Journal of New Drugs , 编辑部邮箱 ,2011年16期
- 【分类号】R971
- 【被引频次】44
- 【下载频次】833