【摘要】 目的:研究灯盏花乙素苷元对大鼠血栓形成、血小板聚集和血液流变学的影响。方法:大鼠连续灌胃灯盏花乙素苷元(100,50,25 mg.kg-1)7 d。电刺激大鼠颈动脉复制动脉血栓模型,记录血栓形成时间;结扎大鼠下腔静脉复制静脉血栓模型,记录血栓湿重和干重;采用0.5×10-4mol.L-1的二磷酸腺苷(adenosine d iphosphate,ADP)诱导血小板聚集,测定最大聚集率;大鼠皮下注射肾上腺素复制血瘀模型,测定红细胞沉降率、全血表观黏度和血浆黏度。同时设灯盏花乙素(100 mg.kg-1)阳性对照。结果:灯盏花乙素苷元能够明显延缓大鼠动脉血栓形成时间,抑制静脉血栓形成,抑制ADP诱导血小板聚集,降低血瘀模型大鼠的红细胞沉降率和血黏度。结论:灯盏花乙素苷元具有抗血栓形成、抗血小板聚集、改善血液流变学指标的作用,疗效优于灯盏花乙素。更多还原

【Abstract】 Objective: To investigate the effects of scutellarein on thrombosis,platelet aggregation and hemorheology in rats.Methods: After oral administration of scutellarein 100,50 or 25mg·kg-1 for 7 days,thrombosis time of carotid artery under electrical stimulation,thrombus weight under inferior vena cava ligation,and ADP-induced platelet aggregation rate were observed.The blood stasis model in rats was established by subcutaneous injection of epinephrine,and erythrocyte sedimentation rate(ESR),whole blood and plasma viscosities were measured.In addition,100mg·kg-1 scutellarin was tested as positive control.Results: Scutellarein dose-dependently depressed arterial or venous thrombosis,and restricted ADP-induced platelet aggregation rate.It also reduced ESR,whole blood and plasma viscosities in rats with blood stasis.Conclusion: Scutellarein can prevent thrombosis and platelet aggregation,and improve the characteristics of hemorheology in rats.更多还原