【摘要】 目的观察帕歌斯治疗原发性膝骨关节炎的疗效及安全性。方法选择原发性膝骨关节炎患者268例,口服帕歌斯治疗8周,观察患者第4、8周及停药后第4周的膝关节压痛指数、活动痛指数、关节肿胀指数和日常活动能力。其中30例肿胀和疼痛较严重的患者进行治疗前、后的CRP和ESR检测。结果各临床观测指标均明显好转,且在第4周和第8周差异有显著性(P<0.05)。其总有效率分别是:第4周:65.6%,第8周:80.8%,停药后第4周:72.4%。不良反应发生率是6.4%。CRP和ESR降至正常。结论帕歌斯治疗原发性膝骨关节炎疗效显著、安全性高、不良反应少且停药后有后续作用。更多还原

【Abstract】 【Objective】 To observe the efficiency and safety of pagosid on treating primary knee osteoarthritis.【Method】 268 patients were given peroral pagosid for 8 weeks,during which the changes of joint tenderness index,movable pain index,joint swelling index and daily activities were detected at the fourth weekend,the eighth weekend and the fourth weekend without medication.30 cases with more serious swelling and pain were performed detection of CRP and ESR before and after treatment.【Results】 We found those indexes decreased throughout the treatment,with effective rates respectively reaching 65.6% at the fourth weekend,80.8% eighth weekend and 72.4% the fourth weekend without medication.And there is a statistical discrepancy of effective rates among the patients when they had been treated for the four weeks and before medication(P <0.05),also between the eight weeks’s time and before medication(P <0.05).The incidence of side effect was 6.4%.Levels of CRP and ESR of all patients decreased to normal.【Conclusions】 Pagosid has significant efficiency,high quality of safety,low side effects and carry-over effects after withdrawal of drug on treating primary knee osteoarthritis.更多还原