【摘要】 目的通过对伪膜性肠炎患者进行回顾性分析,探讨伪膜性肠炎的临床特点、临床特征及治疗与预后,总结临床经验,提高诊治水平。方法回顾性分析2009年6月~2011年5月我院收治的23例伪膜性肠炎患者临床资料。结果 23例患者均表现为腹泻,且腹泻前均有使用抗生素史。18例患者接受内镜检查,15例可见粘膜表面附以多发的黄白色隆起假膜。14例(60.7%)患者年龄≥65岁,17例(73.9%)诊断伪膜性肠炎前住院天数≥10天,12例(39.1%)有腹部大手术史。较长时间质子泵抑制使用,入ICU,机械通气,肠内营养及免疫抑制的使用可在本组患者中观察到。全部病例确诊后,均停用原用的抗生素。应用甲硝唑辅以活菌制剂后症状消失。结论合理应用抗生素,对有危险因素的患者应密切观察病情变化和大便性状,增强对该病的认识及加强其防治是改善预后的关键。更多还原

【Abstract】 【Objective】 To study the clinical characteristic,treatment and prognosis of pseudomembranous colitis by retrospective analysis.【Methods】 23 cases with pseudomembranous colitis admitted to our hospital between June 2009 and May 2011 were investigated and analyzed respectively.【Results】 All patients received the treatment of antibiotics before presenting the symptom of diarrhea.18 cases received endoscopic examination.14 cases(60.7%) were older than 65 years.Length of hospital stay ≥10days was in 12 cases(39.1%).12 cases(39.1%) had history of abdominal surgery.Prolonged use of Proton Pump Inhibitors,ICU admission,mechanical ventilation,enteral nutrition,immunosuppressive agents may be associated with a greater risk of pseudomembranous colitis.All patients discontinue the use of antibiotics and cured by metronidazole and probiotics.【Conclusion】 Reasonable use of antibiotics,close clinical observation,enhancement of the understanding of the disease would improve the prognosis of pseudomembranous colitis.更多还原