【摘要】 目的探讨混合调强放疗在局部晚期和晚期肺癌放射治疗中的剂量学特点。方法对16例不适合做适形放疗的肺癌患者分别设计单纯调强计划和混合调强计划,比较两种计划的剂量学差异。结果两种计划均满足临床要求,而混合调强计划的靶区适形度(CI)和均匀性(HI)均优于调强计划(P<0.05)。混合调强计划中全肺受照5、10、13、15和20Gy剂量的体积V5、V10、V13、V15、V20和平均剂量(MLD)均明显小于调强计划(P<0.05)。结论混合调强明显减少了与放射性肺炎发生率相关的中低剂量照射体积,降低了脏器运动引起的剂量误差,减小了剂量计算误差,对局部晚期和晚期肺癌的放疗有一定的剂量学优势。更多还原

【Abstract】 【Objective】 To explore the dosimetric characteristics of hybrid intensity-modulated radiation therapy(IMRT) for locoregionally and metastatically advanced lung cancer.【Methods】 Both full IMRT plan and hybrid IMRT plan were designed in each of 16 lung cancer patients who were unsuitable for three-dimensional conformal radiation therapy.The dosimetric differences of the two techniques were compared.【Results】 Both the conformity index(CI) and the heterogeneity index(HI) of hybrid IMRT plan were superior to full IMRT plan,though both plans met the clinical requirements(P <0.05).The total irradiated lung volume by 5,10,13,15 or 20 Gy and the mean lung dose(MLD) were significantly reduced when hybrid IMRT plan rather than full IMRT was applied(P <0.05).【Conclusion】 Hybrid IMRT can reduce the irradiated lung volumes under low and intermediate dose which is associated with the radiation pneumonitis.Moreover,the dose deviations due to organ motion and calculation are reduced.Therefore,hybrid IMRT has advantages in radiotherapy dosimetry for locoregionally and metastatically advanced lung cancer.更多还原