Objective To study the effect of local application of different concentrations of nerve growth factor(NGF) on fracture healing,and to further search for the appropriate concentration gradient of NGF to promote fracture healing.Methods Seventy-five adult male Sprague Dawley rats,weighing(220.0±2.5) g,were made the right tibia fracture model at 1 cm distal from the tibial tubercle and randomly divided into 5 groups(groups A,B,C,D,and E,n=15).Fractures were treated with 0.3 mL normal saline containing differen...
【基金】
广西壮族自治区卫生厅科研项目(Z2008095)~~
【更新日期】
2011-06-02
【分类号】
R683
【正文快照】
Chinese Journal of Reparative and Reconstructive Surgery,May 2011,Vol.25,No.5骨折愈合是一个复杂的生理过程,如何促进骨折愈合一直是研究热点。近年来已有研究表明局部给予外源性NGF可促进骨折愈合[1]。本实验进一步探讨NGF促进骨折愈合的适宜浓度梯度,以期为临床应用NGF