【摘要】 目的探讨主动脉Stanford B型主动脉夹层动脉瘤(AD)患者凝血功能的变化及其临床意义。方法 2002-01-2011-01新疆维吾尔自治区人民医院收治Stanford B型主动脉夹层99例,选性别与年龄匹配的正常对照组95例,全自动血凝分析仪检测国际化标准比值(INR)、部分凝血活酶时间(APTT)、纤维蛋白原(FIB)和凝血酶时间(TT)、D-二聚体(DD)。结果 AD组INR、APTT、FIB、DD均高于NC组,TT低于NC组,P<0.01。主动脉夹层分期内比较,亚急性及慢性组夹层INR、FIB高于急性期夹层组,APTT、DD、TT未见明显改变。结论 AD表现为凝血与纤溶持续激活,由于凝血与纤溶间的平衡破坏而产生高凝状态。更多还原

【Abstract】 Objective To explore the changes of blood coagulation function and clinical significances in type B aortic dissection(AD).Methods 99 patients with type B aortic dissection group,95 persons in healthy control group were selected respectively(NC) and the detection and analysis of international normalized ratio(INR),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(Fib) and D-dimer(D-D) were conducted.Results INR,APTT,FIB,DD in AD group significiantly increased compared with NC group,TT decreased respectively(P<0.01).Subact and chronic aortic dissection showed a significant increase in INR,Fib,compared with acute group.Conclusion AD is characterized by activation of both coagulation and fibrinolysis,resulting in an imbalance between coagulation and fibrinolysis leading to a hypercoagulation state.更多还原