【摘要】 促分裂原活化蛋白激酶(MAPK)级联途径是真核生物中高度保守的信号通路。MAPK级联途径由MAPKs、MAPKKs和MAPKKKs组成,通过MAPKKK→MAPKK→MAPK的逐级磷酸化传递细胞信号。AtMEKK1是拟南芥MAPKKK家族中的一员,是目前研究较为详细的MAPKKK。本文就AtMEKK1的结构特征、生理功能、信号转导中的"交谈"及其复杂性进行综述,旨在探讨植物MAPKKK的信号转导作用。更多还原

【Abstract】 Mitogen-activated protein kinase(MAPK) cascades constitute a conserved signaling pathway in eukaryotes.MAPK cascades consist of MAPKs,MAPKKs and MAPKKKs.MAPK cascades transduce signals by sequential phosphorylation(MAPKKK→MAPKK→MAPK).AtMEKK1 is one of the MAPKKKs in Arabidopsis and is the MAPKKK with detailed studies in plant.In this review,we summarized the structural characteristics and physiological functions of AtMEKK1.Furthermore,we discussed the"cross-talk"of AtMEKK1 with other signaling components and signal specificity.This review may shed light on the function of plant MAPKKKs.更多还原