【摘要】 目的:了解掌握福建省2005年-2009年细菌性痢疾病原学特征及耐药特点,为制订细菌性痢疾预防控制措施,指导临床合理用药提供科学依据。方法:复核鉴定监测点送检的阳性菌株,按《全国细菌性痢疾监测方案》提供的方法进行系统检测。结果:四年共复核鉴定菌株137株检出志贺菌97株。其中宋内志贺菌61株,福氏志贺菌36株。分别占检出菌株数的62.9%和37.1%。药敏试验显示9,7株志贺菌对头孢噻肟、头孢克洛、痢特灵及环丙沙星高度敏感,并对萘啶酸、四环素、利福平及复方新诺明等耐药。结论:2005年-2009年福建省分离的菌株以宋内志贺菌所占比重较大,其次为福氏志贺菌。D群宋内志贺菌取代了继往的B群福氏志贺菌,B群志贺菌的F4c亚型取代了继往的福氏2a1、b亚型成为新的流行血清型。并对目前常用的抗菌药物表现一定的耐药性,应引起重视。更多还原

【Abstract】 Objective:To discover the etiological characteristics and antimicrobial susceptibility of Shigella spp.in Fujian province,thus providing suggestion for shigellosis prevention and rational prescriptions in clinics.Methods:Positive Shigella isolates from the surveillance sites were systematically re-identified according to National Protocol of Shigellosis Surveillance.Results:137 positive isolates were re-identified.97 Shigella strains were confirmed,including 61 S.sonnei strains and 36 S.flexneri strains,i.e.62.9% and 37.1% respectively.Susceptibility tests indicated that the 97 Shigella strains were highly sensitive to cefotaxime,cefaclor,ciprofloxacin and furazolidone,but resistant to nalidixic,tetracycline,rifampicin and sulfamethoxazole.Conclusion:The dominant Shigella isolates in Fujian from 2005 to 2009 were S.sonnei,the rest were S.flexneri.Meanwhile,it should be concerned that these isolated possessed considerable resistance to common antibiotics.更多还原