【摘要】 目的:探讨骨折创伤患者血浆纤维蛋白原(Fg)、D-二聚体(DD)以及血小板指标:血小板计数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW)及大血小板比率(P-LCR)与患者病情变化及预后的关系。方法:选择急救120所送多发性骨折创伤患者80例为A组,肢体单处开放性骨折80例为B组;肢体单处骨折80例为C组。3组分别于入院时、术后24 h、术后3 d采集外周静脉血,检测血小板指标、血浆纤维蛋白原(Fg)、D-二聚体(DD),选择同期健康体检者80例为对照组。结果:A组各期纤维蛋白原(Fg)、D-二聚体(DD)和血小板指标与对照组比较,差异有统计学意义(P<0.01),且明显高于B、C组各期(P<0.01);B组各期的D-二聚体(DD)水平较C组、对照组为高(P<0.01),其余指标的差异均无统计学意义(P>0.05);C组指标与对照组比较,差异均无统计学意义(P>0.05)。结论:骨折创伤患者,尤其是多发性创伤机体处于高凝状态。检测Fg、DD、PLT、PDW、MPV和P-LCR对骨折患者引发深静脉栓塞(DVT)及肺栓塞(PE)的发生提供监测指标。更多还原

【Abstract】 Objective:To explore the fibrinogen,D-dimer and the significance of blood platelet index associated with the changes of illness condition and prognosis for the emergency patients suffered from fracture.Methods: The examples of bone fraeture wounded patients delivered by first aid 120 were selected and divided,80 patients with multiple fractures as the A group,limb open fracture of 80 cases of single-limb fractures as B;80 cases at a single group for the C.Admission,after 24 hours and 3 days of operation,peripheral venous blood of the three groups was collected respectively,the Fibrinogen,D-dimer,Platelet count mean platelet volume.Platelet distribution width and Platelet larger cell ratio,and select the same period 80 cases of healthy control group at the same time.Results: The Fibrinogen,D-dimer,Platelet count mean platelet volume.Platelet distribution width and Platelet larger cell ratio of the each period of Group A,compared with Group B,Group C and the control group,was significantly higher(P<0.01).The D-dimer of the each period of Group B,compared with Group C and the control group,was significantly higher(P<0.01).The remaining indicators showed no significant difference(P>0.05);compared with the control group and C group,showed no significant difference(P>0.05).Conclusion: The trauma fracture,especially in multiple trauma patients with hypercoagulable state body,will enhance fibrinolysis.detection of Fg,DD,PLT,PDW,MPV and P-LCR of patients in fracture Deep venous thrombosis(DVT) and Pulmonary embolism(PE) can provide for the occurrence of fracture.更多还原