【摘要】 目的探讨糖类抗原15-3(CA15-3)、癌胚抗原(CEA)及其联合检测对乳腺癌诊断的价值。方法采用电化学发光法检测65例女性乳腺癌患者、45例女性乳腺纤维瘤患者及20例女性乳腺体检正常者血清CA15-3、CEA含量,作灵敏性、特异性、阳性预测值、阴性预测值y、ouden指数、阳性似然比、阴性似然比、及ROC曲线(面积)等指标评价,并应用ROC曲线评估CA15-3、CEA在乳腺癌诊断临界值。结果 CA15-3以阳性预测值、阳性似然比最大;CEA以特异性、阴性似然比最大;CA15-3+CEA联合检测以灵敏性、阴性预测值、youden指数及ROC曲线(面积)最大;CA15-3、CEA在乳腺癌诊断临界值分别为:20.3μ/ml4、.54 ng/ml。结论对CA15-3、CEA及两者联合检测的性能评价可提高乳腺癌早期诊断准确性,提升血清肿瘤标志物(TM)的实际应用价值。更多还原

【Abstract】 Objective To explore the value of serum tumor markers CA15-3,CEA and combined detection them in diagnosing breast cancer.Methods To determine CA15-3 and CEA in serum of 65 breast cancer and 45 fibroadenoma of breast patients,and 20 normal persons by electro chemiluminescent immunoassay(ECLIA),and analyze the sensitivity,specificity,positive predictive value,negative predictive value,youden index,positive likelihood ratio,negative likelihood ratio,ROCcurve through abovementioned markers.The optimal operating point of CA15-3 and CEA were produced by ROC analysis.Results In all of evaluated indicator,the postive prediction value and postive likelihood ratio of CA15-3 were the highest,the sensitivity and negative likelihood ratio of CEA were the highest,the sensitivity,positive predictive value,youden index and ROCcurve of combined assays of CA15-3 and CEA were the highest.The optimal operating point of CA15-3 and CEA were 20.3 μ/ml and 4.54 ng/ml.Conclusion Evaluation of CA15-3,CEA and combined assay of them can increase the diagnostic rate of breast cancer and can advance the practicality value of CA15-3 and CEA.更多还原