【摘要】 【目的】了解乙型肝炎e抗原阴性和阳性HBV/HCV合并感染患者临床特征的异同。【方法】回顾分析我院1999年5月至2010年5月间HCV和HBV合并感染患者总186例;利用SPSS16.0软件,统计分析乙型肝炎e抗原阴性和阳性HBV/HCV合并感染患者的人口学、病毒学和生化学等指标。【结果】186例患者中,e抗原阴性患者140例,e抗原阳性患者46例。e抗原阴性的HBV/HCV合并感染患者与e抗原阳性患者相比,具有年龄较大、TBil水平较高、病毒复制水平低和输血感染居多等特征(P<0.05);但是e抗原阳性合并感染患者ALT水平比e抗原阴性患者明显升高(P=0.031)。e抗原阴性患者HBVDNA阳性比例高于e抗原阴性患者(P=0.000);但是,HCVRNA水平分布无差异(P=0.169)。其他临床特征均无统计学差异。【结论】e抗原阴性和阳性HBV/HCV合并感染患者临床特征存在差异,此差异与HBV单一感染时不同。e抗原仍可以作为HBV/HCV合并感染患者体内HBVDNA复制水平判断指标之一;e抗原状态与HCVRNA的水平无关。更多还原

【Abstract】 [Objective] The purpose of this study was to investigate the clinical characteristics in HBV/HCV co-infected patients with HBeAg-positive and HBeAg-negative.[Methods] A total of 186 HBV/HCV co-infected patients were retrospectively analyzed.The epidemiological,biochemical,and virological characteristics were collected.Univariate analysis was performed with the SPSS 16.0.[Results] Of the 186 cases,140 were HBeAg-negative and 46 were HBeAg-positive.Compared with HBeAg-positive patients,HBeAg-negative patients had elder age,higher TBil levels,higher virus levels and more blood transfusioner(P<0.05).However,ALT levels of HBeAg positive patients were higher than that of HBeAg negative patients(P = 0.031).The rate of HBV DNA positive in HBeAg negative patients was higher than that in HBeAg positive patients(P = 0.000).There was no difference of HCV RNA levels between HBeAg-positive patients and HBeAg-negative patients(P = 0.169).Other clinical characteristics was no difference(P > 0.05).[Conclusions] The clinical characteristics of HBV/HCV co-infection patients with HBeAg-positive and HBeAg-negative were different;these differences were also not same as that of HBV infected patients.HBeAg reflect the HBV DNA levels of HBV/HCV co-infected patients.HBeAg states has nothing to do with the level of HCV RNA.更多还原