【摘要】 【目的】通过检测Annexin A1蛋白在胃癌原发灶和转移灶中表达,探讨Annexin A1表达的病理临床意义及对预后的影响。【方法】构建组织芯片包含胃癌原发灶及相应的转移灶70对、癌旁组织30例,应用免疫组化方法检测Annexin A1在胃癌组织芯片中的表达,结合病理临床资料及生存资料,分析Annexin A1表达与病理临床参数的相关性。【结果】Annexin A1在癌旁组织中不表达,在胃癌原发灶中的阳性表达率为4/70(5.7%),淋巴结转移灶中的表达率为17/70(24.3%),差异有统计学意义(P<0.05)。淋巴结转移灶ANXA1的表达与TNM高分期相关(P<0.05)。Kaplan-Meier分析显示淋巴结转移灶ANXA1表达阳性组患者生存时间较阴性组短,差异有统计学意义(P<0.05)。logistic回归多因素分析ANXA1表达阳性是胃癌早期死亡的危险因素。【结论】Annexin A1的表达与肿瘤的远处转移、胃癌患者的早期死亡密切相关。更多还原

【Abstract】 [Objective] To detect Annexin A1 expression in primary gastric cancer and lymph node metastasis,and explore the association of Annexin A1 expression with clinicopathological features and the prognosis in gastric cancer.[Methods] Tissue microarray blocks,containing 70 pairs of primary gastric cancers and matched metastatic lymph nodes,and 30 cases of adjacent non-tumor gastric tissues were constructed.Expression of ANXA1 in these specimens was analyzed using immunohistochemistry.[Result] ANXA1 was negatively expressed in non-tumor gastric tissues.The positive expression of ANXA1 was detected in 4/70(5.7%)of primary gastric cancers and 17/70(24.3%)of metastatic lymph nodes,respectively.The difference was statistically significant(P < 0.05).Expression of ANXA1 in metastatic lymph nodes was correlated with advanced TNM stages(P < 0.05).In Kaplan-Meier analysis,the survival time was shorter in the patients with metastatic expression of ANXA1 than in those with negative ANXA1 expression(P < 0.05).In logistic regression,metastatic expression of ANXA1 is a risk factor associated with patient early death.[Conclusion] ANXA1 expression was significantly related with gastric cancer distant metastasis and patient early death.更多还原